Familial correlations for age at onset and age at death in Huntington's disease.

Familial correlations for age at onset and age at death in Huntington's disease.

Testing for familial correlation in age-at-onset.

The analysis of family-study data sometimes focuses on whether a dichotomous trait tends to cluster in families. For traits with variable age-at-onset, it may be of interest to investigate whether age-at-onset itself also exhibits familial clustering. A complication in such investigations is that censoring by age-at-ascertainment can induce artifactual familial correlation in the age-at-onset o...

Age at onset and Parkinson disease phenotype.

OBJECTIVE To explore clinical phenotype and characteristics of Parkinson disease (PD) at different ages at onset in recently diagnosed patients with untreated PD. METHODS We have analyzed baseline data from the Parkinson's Progression Markers Initiative database. Four hundred twenty-two patients with a diagnosis of PD confirmed by DaTSCAN imaging were divided into 4 groups according to age at...

Age at onset in Huntington's disease and methylation at D4S95.

Age at onset in Huntington's disease (HD) is variable and is influenced by parental sex, paternal age, and genetic background. Several recent models have tried to explain this variable expressivity by invoking parental imprinting and related aspects of epigenetic inheritance. Some of these mechanisms may result in variable DNA methylation at or near the HD gene. We show here that methylation at...

RELATIONSHIP BETWEEN KNEE MALALIGNMENT AND QANGLE WITH AGE AT ONSET OF DISEASE IN 260 CHONDROMALACIA PATELLA PATIENTS

Background: Chondromalacia patella is the most common cause of mechanical knee pain in young women. Q angle and knee alignment are important clinical parameters for biomechanics of the patellofemoral joint. Objective: To identify the prevalence of knee malalignment and to find out if there is a correlation between knee mal alignment and Q angle with age at onset of disease. Methods: All pa...